Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute kidney injury. For this reason, a suitable deliv...

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Bibliographic Details
Main Authors: Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
central composite design
solid lipid nanoparticles
acyclovir
bioavailability
oral delivery
Online Access:https://www.mdpi.com/1420-3049/26/18/5432

Internet

https://www.mdpi.com/1420-3049/26/18/5432

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