A Decade Of Boon Or Burden: What Has The CHIP Ever Done For Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration And Ageing?

A Decade Of Boon Or Burden: What Has The CHIP Ever Done For Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration And Ageing?

Cells regularly synthesize new proteins to replace old and abnormal proteins for normal cellular functions. Two significant protein quality control pathways inside the cellular milieu are ubiquitin proteasome system (UPS) and autophagy. Autophagy is known for bulk clearance of cytoplasmic aggregated...

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Bibliographic Details
Main Authors: Vibhuti Joshi, Ayeman Amanullah, Arun Upadhyay, Ribhav Mishra, Amit Kumar, Amit Mishra
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Cell Death
Ageing
neurodegeneration
E3 ubiquitin ligases
Misfolded proteins
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00093/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00093/full

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