Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling.

Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling.

Recent evidence suggests that aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas including ovarian cancer. Therefore, chemotherapeutic agents that inhibit activation of Gli transcription factors have emerged as pr...

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Bibliographic Details
Main Authors: Qi Chen, Rong Xu, Chunyan Zeng, Quqin Lu, Dengliang Huang, Chao Shi, Weilong Zhang, Libin Deng, Runwei Yan, Hai Rao, Guolan Gao, Shiwen Luo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3922814?pdf=render

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http://europepmc.org/articles/PMC3922814?pdf=render

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