The Effect of Modified Porcine Surfactant Alone or in Combination with Polymyxin B on Lung Homeostasis in LPS-Challenged and Mechanically Ventilated Adult Rats

The Effect of Modified Porcine Surfactant Alone or in Combination with Polymyxin B on Lung Homeostasis in LPS-Challenged and Mechanically Ventilated Adult Rats

The study aimed to prove the hypothesis that exogenous surfactant and an antibiotic polymyxin B (PxB) can more effectively reduce lipopolysaccharide (LPS)-induced acute lung injury (ALI) than surfactant treatment alone, and to evaluate the effect of this treatment on the gene expression of surfactan...

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Bibliographic Details
Main Authors: Maros Kolomaznik, Jana Kopincova, Zuzana Nova, Juliana Topercerova, Ivan Zila, Pavol Mikolka, Petra Kosutova, Katarina Matasova, Henrieta Skovierova, Marian Grendar, Daniela Mokra, Andrea Calkovska
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
ARDS
bacterial lipopolysaccharide
pulmonary surfactant
surfactant proteins
Online Access:https://www.mdpi.com/1420-3049/25/19/4356

Internet

https://www.mdpi.com/1420-3049/25/19/4356

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