The RNA-Binding Proteins SRP14 and HMGB3 Control HIV-1 Tat mRNA Processing and Translation During HIV-1 Latency

The RNA-Binding Proteins SRP14 and HMGB3 Control HIV-1 Tat mRNA Processing and Translation During HIV-1 Latency

HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate Tat production may be absent or downregulated in resting CD4+ T-cells, the main reservoir of latent HIV in people with HIV (PWH) on antiretroviral therapy (ART). In this study, we examined the role of Tat RNA-b...

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Bibliographic Details
Main Authors: Georges Khoury, Michelle Y. Lee, Sri H. Ramarathinam, James McMahon, Anthony W. Purcell, Secondo Sonza, Sharon R. Lewin, Damian F. J. Purcell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Genetics
Subjects:
HIV-1
latency
tat mRNA
SRP14
HMGB3
mRNA processing
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.680725/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.680725/full

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