The CCR5Δ32 Polymorphism in Brazilian Patients with Sickle Cell Disease

Background. Previous studies on the role of inflammation in the pathophysiology of sickle cell disease (SCD) suggested that the CCR5Δ32 allele, which is responsible for the production of truncated C-C chemokine receptor type 5 (CCR5), could confer a selective advantage on patients with SCD because i...

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Main Authors: Mariana Pezzute Lopes, Magnun Nueldo Nunes Santos, Eliel Wagner Faber, Marcos André Cavalcanti Bezerra, Betânia Lucena Domingues Hatzlhofer, Dulcinéia Martins Albuquerque, Tânia Regina Zaccariotto, Daniela Maria Ribeiro, Aderson da Silva Araújo, Fernando Ferreira Costa, Maria de Fátima Sonati
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2014/678246