Correlation of PKM2 and CD44 Protein Expression with Poor Prognosis in Platinum-Treated Epithelial Ovarian Cancer: A Retrospective Study

Correlation of PKM2 and CD44 Protein Expression with Poor Prognosis in Platinum-Treated Epithelial Ovarian Cancer: A Retrospective Study

CD44, a surface marker for cancer stem cells, interacts with PKM2, a key regulator of aerobic glycolysis, and enhances the glycolytic phenotype of cancer cells leading to antioxidant protection and macromolecules’ synthesis. To clarify the clinical importance of this “cross-talk” as a mechanism of d...

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Bibliographic Details
Main Authors: Chara Papadaki, Stavroula Manolakou, Eleni Lagoudaki, Spyros Pontikakis, Despo Ierodiakonou, Konstantinos Vogiatzoglou, Ippokratis Messaritakis, Maria Trypaki, Linda Giannikaki, Maria Sfakianaki, Antonia Kalykaki, Dimitrios Mavroudis, Maria Tzardi, John Souglakos
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
CD44
PKM2
platinum-resistance
ovarian cancer
Online Access:https://www.mdpi.com/2072-6694/12/4/1013

Internet

https://www.mdpi.com/2072-6694/12/4/1013

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