Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells

Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells

During myocardial infarction, microRNAs (myo-miRs) are released into the circulation. Here Cheng et al. show that myo-miRs carried in exosomes are transferred to the bone marrow (BM), downregulate expression of CXCR4 in mononuclear cells, and increase the number of circulating BM progenitor cells, t...

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Bibliographic Details
Main Authors: Min Cheng, Junjie Yang, Xiaoqi Zhao, Eric Zhang, Qiutang Zeng, Yang Yu, Liu Yang, Bangwei Wu, Guiwen Yi, Xiaobo Mao, Kai Huang, Nianguo Dong, Min Xie, Nita A. Limdi, Sumanth D. Prabhu, Jianyi Zhang, Gangjian Qin
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08895-7

Internet

https://doi.org/10.1038/s41467-019-08895-7

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