SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines

SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines

Background/Aims: Many tubulin inhibitors are in clinical use as anti-cancer drugs. In our previous study, a novel series of 4-substituted coumarins derivatives were identified as novel tubulin inhibitors. Here, we report the anti-cancer activity and underlying mechanism of one of the 4-substituted c...

Full description

Bibliographic Details
Main Authors: Wei Yan, Tao Yang, Jianhong Yang, Taijin Wang, Yamei Yu, Yuxi Wang, Qiang Chen, Peng Bai, Dan Li, Haoyu Ye, Qiang Qiu, Yongzhao Zhou, Yiguo Hu, Shengyong Yang, Yuquan Wei, Weimin Li, Lijuan Chen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Tubulin
Cancer
Colchicine
Reversible
4-substituted coumarins
SKLB060
Multidrug Resistance
Online Access:https://www.karger.com/Article/FullText/489983

Internet

https://www.karger.com/Article/FullText/489983

Similar Items