Transient receptor potential melastatin 2–mediated heme oxygenase-1 has a role for bacterial clearance by regulating autophagy in peritoneal macrophages during polymicrobial sepsis

Our previous study indicated an important protective role of transient receptor potential melastatin 2 (TRPM2) in controlling bacterial clearance in macrophages during polymicrobial sepsis by regulating heme oxygenase-1. Autophagy is necessary for macrophages to kill invasive bacteria. In the presen...

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Bibliographic Details
Main Authors: XiaoWei Qian, Hao Cheng, XinZhong Chen
Format: Article
Language:English
Published: SAGE Publishing 2019-11-01
Series:Innate Immunity
Online Access:https://doi.org/10.1177/1753425919875796