Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

Broadly neutralizing antibodies (bnAbs) isolated from HIV-infected individuals delineate vulnerable sites on the HIV envelope glycoprotein that are potential vaccine targets. A linear epitope within the N-terminal region of the HIV-1 fusion peptide (FP8) is the primary target of VRC34.01, a bnAb tha...

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Bibliographic Details
Main Authors: Alemu Tekewe Mogus, Lihong Liu, Manxue Jia, Diane T. Ajayi, Kai Xu, Rui Kong, Jing Huang, Jian Yu, Peter D. Kwong, John R. Mascola, David D. Ho, Moriya Tsuji, Bryce Chackerian
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Vaccines
Subjects:
broadly neutralizing antibody
HIV-1 fusion peptide
HIV-1 DS-SOSIP trimer
prime-boost immunizations
vaccine
virus-like particles
Online Access:https://www.mdpi.com/2076-393X/8/4/765

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https://www.mdpi.com/2076-393X/8/4/765

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