Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia

Introduction and Objectives: Cardiovascular disease is the leading cause of mortality and morbidity associated with diabetes. Although impairment of the cell response to hypoxia due to destabilization of the transcription factor hypoxia-inducible factor-1α (HIF-1α), which regulates the expression of...

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Bibliographic Details
Main Authors: Ana Rita Ramalho, Adriana Toscano, Paulo Pereira, Henrique Girão, Lino Gonçalves, Carla Marques
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Revista Portuguesa de Cardiologia (English Edition)
Online Access:http://www.sciencedirect.com/science/article/pii/S2174204917301356