Hyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia
Introduction and Objectives: Cardiovascular disease is the leading cause of mortality and morbidity associated with diabetes. Although impairment of the cell response to hypoxia due to destabilization of the transcription factor hypoxia-inducible factor-1α (HIF-1α), which regulates the expression of...
Main Authors: | Ana Rita Ramalho, Adriana Toscano, Paulo Pereira, Henrique Girão, Lino Gonçalves, Carla Marques |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-05-01
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Series: | Revista Portuguesa de Cardiologia (English Edition) |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2174204917301356 |
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