Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple <i>DPYD</i> Variants

Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple <i>DPYD</i> Variants

<i>DPYD</i> genotyping prior to fluoropyrimidine treatment is increasingly implemented in clinical care. Without phasing information (i.e., allelic location of variants), current genotype-based dosing guidelines cannot be applied to patients carrying multiple <i>DPYD</i> vari...

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Bibliographic Details
Main Authors: Carin A. T. C. Lunenburg, Linda M. Henricks, André B. P. van Kuilenburg, Ron H. J. Mathijssen, Jan H. M. Schellens, Hans Gelderblom, Henk-Jan Guchelaar, Jesse J. Swen
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Genes
Subjects:
pharmacogenomics
pharmacogenetics
genotype
phenotype
alleles
precision medicine
Online Access:https://www.mdpi.com/2073-4425/9/12/585

Internet

https://www.mdpi.com/2073-4425/9/12/585

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