Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

Transient, regulated binding of globular protein domains to Short Linear Motifs (SLiMs) in disordered regions of other proteins drives cellular signaling. Mapping the energy landscapes of these interactions is essential for deciphering and perturbing signaling networks but is challenging due to thei...

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Bibliographic Details
Main Authors: Huy Quoc Nguyen, Jagoree Roy, Björn Harink, Nikhil P Damle, Naomi R Latorraca, Brian C Baxter, Kara Brower, Scott A Longwell, Tanja Kortemme, Kurt S Thorn, Martha S Cyert, Polly Morrell Fordyce
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
microfluidics
spectral encoding
calcineurin
protein-peptide interactions
protein specificity
phophatase specificity
Online Access:https://elifesciences.org/articles/40499

Internet

https://elifesciences.org/articles/40499

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