Oral (−)-Epicatechin Inhibits Progressive Tau Pathology in rTg4510 Mice Independent of Direct Actions at GSK3β

Oral (−)-Epicatechin Inhibits Progressive Tau Pathology in rTg4510 Mice Independent of Direct Actions at GSK3β

Aggregation of the microtubule-associated protein tau into paired helical filaments (PHFs) and neurofibrillary tangles is a defining characteristic of Alzheimer’s Disease. Various plant polyphenols disrupt tau aggregation in vitro but display poor bioavailability and low potency, challenging their t...

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Bibliographic Details
Main Authors: Katriona L. Hole, Lydia E. Staniaszek, Gayathri Menon Balan, Jody M. Mason, Jon T. Brown, Robert J. Williams
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
Tau & phospho-Tau protein
flavonoid
glycogen synthase kinase 3 β
dementia
rTg4510 mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.697319/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.697319/full

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