Transposon mutagenesis of probiotic Lactobacillus casei identifies asnH, an asparagine synthetase gene involved in its immune-activating capacity.

Transposon mutagenesis of probiotic Lactobacillus casei identifies asnH, an asparagine synthetase gene involved in its immune-activating capacity.

Lactobacillus casei ATCC 27139 enhances host innate immunity, and the J1 phage-resistant mutants of this strain lose the activity. A transposon insertion mutant library of L. casei ATCC 27139 was constructed, and nine J1 phage-resistant mutants out of them were obtained. Cloning and sequencing analy...

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Bibliographic Details
Main Authors: Masahiro Ito, Yun-Gi Kim, Hirokazu Tsuji, Takuya Takahashi, Mayumi Kiwaki, Koji Nomoto, Hirofumi Danbara, Nobuhiko Okada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3885529?pdf=render

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http://europepmc.org/articles/PMC3885529?pdf=render

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