Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells.

Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells.

Lysosomal enzymes function optimally in acidic environments, and elevation of lysosomal pH can impede their ability to degrade material delivered to lysosomes through autophagy or phagocytosis. We hypothesize that abnormal lysosomal pH is a key aspect in diseases of accumulation and that restoring l...

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Bibliographic Details
Main Authors: Gabriel C Baltazar, Sonia Guha, Wennan Lu, Jason Lim, Kathleen Boesze-Battaglia, Alan M Laties, Puneet Tyagi, Uday B Kompella, Claire H Mitchell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3525582?pdf=render

Internet

http://europepmc.org/articles/PMC3525582?pdf=render

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