A Bioengineered Neuregulin-Hydrogel Therapy Reduces Scar Size and Enhances Post-Infarct Ventricular Contractility in an Ovine Large Animal Model

A Bioengineered Neuregulin-Hydrogel Therapy Reduces Scar Size and Enhances Post-Infarct Ventricular Contractility in an Ovine Large Animal Model

The clinical efficacy of neuregulin (NRG) in the treatment of heart failure is hindered by off-target exposure due to systemic delivery. We previously encapsulated neuregulin in a hydrogel (HG) for targeted and sustained myocardial delivery, demonstrating significant induction of cardiomyocyte proli...

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Bibliographic Details
Main Authors: Jeffrey E. Cohen, Andrew B. Goldstone, Hanjay Wang, Brendan P. Purcell, Yasuhiro Shudo, John W. MacArthur, Amanda N. Steele, Michael J. Paulsen, Bryan B. Edwards, Chiaka N. Aribeana, Nicholas C. Cheung, Jason A. Burdick, Y. Joseph Woo
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
neuregulin
hydrogel
myocardial infarction
ischemic heart failure
Online Access:https://www.mdpi.com/2308-3425/7/4/53

Internet

https://www.mdpi.com/2308-3425/7/4/53

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