Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation

Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation

The pentaspan membrane glycoprotein CD133 marks lineage-specific cancer progenitor cells and is associated with poor prognosis in a number of tumor types. Despite its utility as a cancer progenitor cell marker, CD133 protein regulation and molecular function remain poorly understood. We find that t...

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Bibliographic Details
Main Authors: Anthony B. Mak, Allison M.L. Nixon, Saranya Kittanakom, Jocelyn M. Stewart, Ginny I. Chen, Jasna Curak, Anne-Claude Gingras, Ralph Mazitschek, Benjamin G. Neel, Igor Stagljar, Jason Moffat
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712003208

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http://www.sciencedirect.com/science/article/pii/S2211124712003208

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