THE ROLE OF INDY IN METABOLIC REGULATION

Reduced expression of the Indy (I'm Not Dead Yet) gene in D. melanogaster and C. elegans extends longevity. Indy and its mammalian homolog mINDY (Slc13a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol. Deletion...

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Bibliographic Details
Main Authors: Diana M Willmes, Andreas L Birkenfeld
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S200103701460129X