Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy

Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy

Mesio-temporal lobe epilepsy (MTLE), the most common drug-resistant epilepsy syndrome, is characterized by the recurrence of spontaneous focal seizures after a latent period that follows, in most patients, an initial insult during early childhood. Many of the mechanisms that have been associated wit...

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Bibliographic Details
Main Authors: Christophe Heinrich, Sari Lähteinen, Fumio Suzuki, Laharie Anne-Marie, Susanne Huber, Ute Häussler, Carola Haas, Yves Larmet, Eero Castren, Antoine Depaulis
Format: Article
Language:English
Published: Elsevier 2011-04-01
Series:Neurobiology of Disease
Subjects:
Neurotrophin
Neuronal plasticity
Dentate gyrus
Ammon's horn sclerosis
Granule cell dispersion
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000027

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http://www.sciencedirect.com/science/article/pii/S0969996111000027

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