Evolution-Based Functional Decomposition of Proteins.

The essential biological properties of proteins-folding, biochemical activities, and the capacity to adapt-arise from the global pattern of interactions between amino acid residues. The statistical coupling analysis (SCA) is an approach to defining this pattern that involves the study of amino acid...

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Bibliographic Details
Main Authors: Olivier Rivoire, Kimberly A Reynolds, Rama Ranganathan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4890866?pdf=render