Adverse Effects of Methylglyoxal on Transcriptome and Metabolic Changes in Visceral Adipose Tissue in a Prediabetic Rat Model

Adverse Effects of Methylglyoxal on Transcriptome and Metabolic Changes in Visceral Adipose Tissue in a Prediabetic Rat Model

Excessive methylglyoxal (MG) production contributes to metabolic and vascular changes by increasing inflammatory processes, disturbing regulatory mechanisms and exacerbating tissue dysfunction. MG accumulation in adipocytes leads to structural and functional changes. We used transcriptome analysis t...

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Bibliographic Details
Main Authors: Martina Hüttl, Irena Markova, Denisa Miklankova, Pavol Makovicky, Terezie Pelikanova, Ondrej Šeda, Lucie Šedová, Hana Malinska
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Antioxidants
Subjects:
methylglyoxal
adipose tissue
insulin resistance
Online Access:https://www.mdpi.com/2076-3921/9/9/803

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https://www.mdpi.com/2076-3921/9/9/803

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