Factor analysis for gene regulatory networks and transcription factor activity profiles

<p>Abstract</p> <p>Background</p> <p>Most existing algorithms for the inference of the structure of gene regulatory networks from gene expression data assume that the activity levels of transcription factors (TFs) are proportional to their mRNA levels. This assumption i...

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Bibliographic Details
Main Authors: Wernisch Lorenz, Pournara Iosifina
Format: Article
Language:English
Published: BMC 2007-02-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/8/61