Magnesium isoglycyrrhizinate ameliorates radiation-induced pulmonary fibrosis by inhibiting fibroblast differentiation via the p38MAPK/Akt/Nox4 pathway

Magnesium isoglycyrrhizinate ameliorates radiation-induced pulmonary fibrosis by inhibiting fibroblast differentiation via the p38MAPK/Akt/Nox4 pathway

Radiation-induced pulmonary fibrosis (RIPF) is a severe complication in patients treated with thoracic irradiation. Until now, there are no effective therapeutic drugs for RIPF. In the present study, we attempted to evaluate the effect of Magnesium isoglycyrrhizinate (MgIG) on RIPF, and to further e...

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Bibliographic Details
Main Authors: Qunfang Yang, Pan Zhang, Tao Liu, Xuan Zhang, Xichun Pan, Yanyan Cen, Ya Liu, Haigang Zhang, Xiaohong Chen
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Magnesium isoglycyrrhizinate
Radiation
Pulmonary fibrosis
Fibroblast differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219305499

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http://www.sciencedirect.com/science/article/pii/S0753332219305499

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