TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

CD8+ T cell anergy is a critical mechanism of peripheral tolerance, poorly investigated in response to immunotherapy. Here, using a pancreatic islet allograft model and CD3 antibody therapy, we showed, by single cell gene profiling, that intragraft CD8+ lymphocytes coexpressing granzyme B and perfor...

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Bibliographic Details
Main Authors: Marije Baas, Alix Besançon, Tania Goncalves, Fabrice Valette, Hideo Yagita, Birgit Sawitzki, Hans-Dieter Volk, Emmanuelle Waeckel-Enée, Benedita Rocha, Lucienne Chatenoud, Sylvaine You
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
tolerance
CD8+ T cells
TGF-beta
PD-1/PD-L1
tranplantation
anergy
Online Access:https://elifesciences.org/articles/08133

Internet

https://elifesciences.org/articles/08133

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