Alternative processing of the U2 small nuclear RNA produces a 19-22nt fragment with relevance for the detection of non-small cell lung cancer in human serum.

Alternative processing of the U2 small nuclear RNA produces a 19-22nt fragment with relevance for the detection of non-small cell lung cancer in human serum.

RNU2 exists in two functional forms (RNU2-1 and RNU2-2) distinguishable by the presence of a unique 4-bases motif. Detailed investigation of datasets obtained from deep sequencing of five human lung primary tumors revealed that both forms express at a high rate a 19-22nt fragment (miR-U2-1 and -2) f...

Full description

Bibliographic Details
Main Authors: Julien Mazières, Caroline Catherinne, Olivier Delfour, Sandrine Gouin, Isabelle Rouquette, Marie-Bernadette Delisle, Grégoire Prévot, Roger Escamilla, Alain Didier, David H Persing, Mike Bates, Bernard Michot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3603938?pdf=render

Internet

http://europepmc.org/articles/PMC3603938?pdf=render

Similar Items