Exome-Wide Search for Genes Associated With Central Nervous System Inflammatory Demyelinating Diseases Following CHIKV Infection: The Tip of the Iceberg

Exome-Wide Search for Genes Associated With Central Nervous System Inflammatory Demyelinating Diseases Following CHIKV Infection: The Tip of the Iceberg

Chikungunya virus (CHIKV) is a re-emergent arbovirus that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia, although <1% of cases develop severe neurological manifestations such as inflammatory demyelinating diseases (IDD) of the central nervous sys...

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Main Authors: Soniza Vieira Alves-Leon, Cristina dos Santos Ferreira, Alice Laschuk Herlinger, Fabricia Lima Fontes-Dantas, Fernanda Cristina Rueda-Lopes, Ronaldo da Silva Francisco, João Paulo da Costa Gonçalves, Amanda Dutra de Araújo, Cláudia Cecília da Silva Rêgo, Luiza Mendonça Higa, Alexandra Lehmkuhl Gerber, Ana Paula de Campos Guimarães, Mariane Talon de Menezes, Marcelo Calado de Paula Tôrres, Richard Araújo Maia, Bruno Miceli Gonzalez Nogueira, Laise Carolina França, Marcos Martins da Silva, Christian Naurath, Aline Saraiva da Silva Correia, Claudia Cristina Ferreira Vasconcelos, Amilcar Tanuri, Orlando Costa Ferreira, Cynthia Chester Cardoso, Renato Santana Aguiar, Ana Tereza Ribeiro de Vasconcelos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
whole exome sequence
chikungunya
pathogenic variants
HLA alleles
inflammatory demyelinating diseases
neurological manifestations in viral infection
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.639364/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.639364/full

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