Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens

Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens

Summary: Tumors with an impaired transporter associated with antigen processing (TAP) present several endoplasmic reticulum-derived self-antigens on HLA class I (HLA-I) which are absent on healthy cells. Selection of such TAP-independent antigens for T cell-based immunotherapy should include analysi...

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Bibliographic Details
Main Authors: Antonius A. de Waard, Tamara Verkerk, Kelly Hoefakker, Dirk M. van der Steen, Marlieke L.M. Jongsma, Dganit Melamed Kadosh, Sophie Bliss, Arnoud H. de Ru, Arie Admon, Peter A. van Veelen, Marieke Griffioen, Mirjam H.M. Heemskerk, Robbert M. Spaapen
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:iScience
Subjects:
Immunology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221000195

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http://www.sciencedirect.com/science/article/pii/S2589004221000195

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