Ulinastatin suppresses endoplasmic reticulum stress and apoptosis in the hippocampus of rats with acute paraquat poisoning

Lung injury is the main manifestation of paraquat poisoning. Few studies have addressed brain damage after paraquat poisoning. Ulinastatin is a protease inhibitor that can effectively stabilize lysosomal membranes, prevent cell damage, and reduce the production of free radicals. This study assumed t...

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Bibliographic Details
Main Authors:	Hai-feng Li, Shi-xing Zhao, Bao-peng Xing, Ming-li Sun
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2015-01-01
Series:	Neural Regeneration Research
Subjects:	tamoxifen Src kinase PP2 trauma regeneration neuroprotection auranofin dextromethorphan rosiglitazone Alzheimer′s disease neuroinflammation neurodegeneration microglia astrocytes nerve regeneration spinal cord electroacupuncture therapy neural stem cells notch signaling pathway inflammation survival curve proliferation differentiation real-time quantitative PCR western blot assay neural regeneration superparamagnetic iron oxide magnetic guidance bone marrow mesenchymal stem cells spinal cord injury cell transplantation magnetic resonance image lumbar puncture spinal cord transection average combined score magnetic resonance imaging diffusion tensor imaging fractional anisotropy apparent diffusion coefficient fiber tractography peripheral nerve injury sciatic nerve hypothermia blood-nerve barrier Evans blue tracer neural degeneration polyethyleneimine-polyethylene glycol spiral ganglion cells X-linked inhibitor of apoptosis protein gene therapy nanocarrier cisplatin ototoxicity cochlea ocular hypertension JNK3 retinal ganglion cell glaucoma laser photocoagulation intraocular pressure brain injury apoptosis cerebral ischemia SMAD3 transforming growth factor β1 NSFC grant Chinese herbal formula Tneurotrophic factor ongluo Jiunao injection nerve growth factor receptor Xuesai Tong hippocampus dentate gyrus lipid peroxidation type 1 diabetes malondialdehyde neurons acupuncture cerebral hemorrhage immunohistochemistry Notch1 Hes1 rats DAPT transcranial direct current stimulation visuomotor coordination task difficulty primary motor area motor learning paraquat poisoning endoplasmic reticulum stress ulinastatin CHOP GRP78 caspase-3 reactive oxygen species
Online Access:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=3;spage=467;epage=472;aulast=Li

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=3;spage=467;epage=472;aulast=Li

Ulinastatin suppresses endoplasmic reticulum stress and apoptosis in the hippocampus of rats with acute paraquat poisoning

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