A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.

A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.

Spatial regulation of the tumor suppressor PTEN is exerted through alternative plasma membrane, cytoplasmic, and nuclear subcellular locations. The N-terminal region of PTEN is important for the control of PTEN subcellular localization and function. It contains both an active nuclear localization si...

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Bibliographic Details
Main Authors: Anabel Gil, Isabel Rodríguez-Escudero, Miriam Stumpf, María Molina, Víctor J Cid, Rafael Pulido
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4398541?pdf=render

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http://europepmc.org/articles/PMC4398541?pdf=render

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