The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas

The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas

Background: Malignant gliomas are heterogeneous brain tumors with the potential for aggressive disease progression, as influenced by suppressive immunoediting. Given the success and enhanced potential of immune-checkpoint inhibitors in immunotherapy, we focused on the connections between genetic alt...

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Bibliographic Details
Main Authors: Luyan Mu, Yu Long, Changlin Yang, Linchun Jin, Haipeng Tao, Haitao Ge, Yifan E. Chang, Aida Karachi, Paul S. Kubilis, Gabriel De Leon, Jiping Qi, Elias J. Sayour, Duane A. Mitchell, Zhiguo Lin, Jianping Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
gliomas
immune checkpoint
PD-L1
DNA methylation
IDH mutation
2-hydroxyglutarate
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00082/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00082/full

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