Ischemic postconditioning prevents surge of presynaptic glutamate release by activating mitochondrial ATP-dependent potassium channels in the mouse hippocampus.

Ischemic postconditioning prevents surge of presynaptic glutamate release by activating mitochondrial ATP-dependent potassium channels in the mouse hippocampus.

A mild ischemic load applied after a lethal ischemic insult reduces the subsequent ischemia-reperfusion injury, and is called ischemic postconditioning (PostC). We studied the effect of ischemic PostC on synaptic glutamate release using a whole-cell patch-clamp technique. We recorded spontaneous exc...

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Bibliographic Details
Main Authors: Shohei Yokoyama, Ichiro Nakagawa, Yoichi Ogawa, Yudai Morisaki, Yasushi Motoyama, Young Su Park, Yasuhiko Saito, Hiroyuki Nakase
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0215104

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https://doi.org/10.1371/journal.pone.0215104

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