Mesenchymal Stem Cell Protection of Neurons against Glutamate Excitotoxicity Involves Reduction of NMDA-Triggered Calcium Responses and Surface GluR1, and Is Partly Mediated by TNF

Mesenchymal Stem Cell Protection of Neurons against Glutamate Excitotoxicity Involves Reduction of NMDA-Triggered Calcium Responses and Surface GluR1, and Is Partly Mediated by TNF

Mesenchymal stem cells (MSC) provide therapeutic effects in experimental CNS disease models and show promise as cell-based therapies for humans, but their modes of action are not well understood. We previously show that MSC protect rodent neurons against glutamate excitotoxicity in vitro, and in viv...

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Bibliographic Details
Main Authors: Irini Papazian, Vasiliki Kyrargyri, Maria Evangelidou, Anda Voulgari-Kokota, Lesley Probert
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
neurodegeneration
neuroprotection
neuronal Ca2+ signaling
glutamate receptors
NMDA
AMPA receptors
TNF
multiple sclerosis
Online Access:http://www.mdpi.com/1422-0067/19/3/651

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http://www.mdpi.com/1422-0067/19/3/651

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