Sodium Tanshinone II Sulfonate A Ameliorates Hypoxia-Induced Pulmonary Hypertension

Sodium Tanshinone II Sulfonate A Ameliorates Hypoxia-Induced Pulmonary Hypertension

BackgroundPulmonary hypertension (PH) remains a prevalent disease globally. Sodium tanshinone II sulfonate A (STS) has been used in clinical treatment of PH.AimsThe aim of the present study was to investigate the effect of sodium STS treatment on hypoxia-induced PH and related mechanisms.MethodsMale...

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Bibliographic Details
Main Authors: Ya-Ru Bao, Jing-Wei Chen, Yan Jiang, Lin-Hui Wang, Rong Xue, Jin-Xian Qian, Guo-Xing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
hypoxic pulmonary hypertension
sodium tanshinone II sulfonate A (STS)
apoptosis
PI3K/Akt//mTOR signaling pathway
autophagy
inflammatory factors
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00687/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00687/full

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