Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration

Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration

Abstract Background Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans. However, whether and how the nature of the CNS insult—acute versus chronic—influences the astrocyte response, and whether astro...

Full description

Bibliographic Details
Main Authors: Sudeshna Das, Zhaozhi Li, Ayush Noori, Bradley T. Hyman, Alberto Serrano-Pozo
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Neuroinflammation
Subjects:
Acute CNS injury
Astrocyte reaction
Meta-analysis
Neurodegenerative diseases
Transcriptomics
Online Access:http://link.springer.com/article/10.1186/s12974-020-01898-y

Internet

http://link.springer.com/article/10.1186/s12974-020-01898-y

Similar Items