Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability.
Genomic instability is a major driver of intra-tumor heterogeneity. However, unstable genomes often exhibit different molecular and clinical phenotypes, which are associated with distinct mutational processes. Here, we algorithmically inferred the clonal phylogenies of ~6,000 human tumors from 32 tu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-09-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC6155543?pdf=render |