Landscape of circulating tumour DNA in metastatic breast cancer

Landscape of circulating tumour DNA in metastatic breast cancer

Background: We describe the genomic landscape of circulating tumour DNA (ctDNA) across pathological subtypes of metastatic breast cancer. Methods: 255 clinically annotated patients with ctDNA testing by Guardant360 were stratified into HR+, HER2+, and TNBC cohorts. Frequency and heterogeneity of alt...

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Bibliographic Details
Main Authors: Andrew A. Davis, Saya Jacob, Lorenzo Gerratana, Ami N. Shah, Firas Wehbe, Neelima Katam, Qiang Zhang, Lisa Flaum, Kalliopi P. Siziopikou, Leonidas C. Platanias, William J. Gradishar, Amir Behdad, Massimo Cristofanilli
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:EBioMedicine
Subjects:
Circulating tumour DNA
cell-free DNA
Next-generation sequencing
Genomics
Metastatic breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302899

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http://www.sciencedirect.com/science/article/pii/S2352396420302899

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