Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes

Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes

Clozapine has stronger systemic metabolic side effects than haloperidol and it was hypothesized that therapeutic antipsychotic and adverse metabolic effects might be related. Considering that cerebral disconnectivity through oligodendrocyte dysfunction has been implicated in schizophrenia, it is imp...

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Bibliographic Details
Main Authors: Johann eSteiner, Daniel eMartins-de-Souza, Kolja eSchiltz, Zoltan eSarnyai, Sabine eWestphal, Berend eIsermann, Henrik eDobrowolny, Christoph eTurck, Bernhard eBogerts, Hans-Gert eBernstein, Tamas L Horvath, Lorenz eSchild, Gerburg eKeilhoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Clozapine
Glycolysis
Haloperidol
Schizophrenia
myelin
oligodendrocytes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00384/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00384/full

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