Mechanisms Underlying Spontaneous Action Potential Generation Induced by Catecholamine in Pulmonary Vein Cardiomyocytes: A Simulation Study

Mechanisms Underlying Spontaneous Action Potential Generation Induced by Catecholamine in Pulmonary Vein Cardiomyocytes: A Simulation Study

Cardiomyocytes and myocardial sleeves dissociated from pulmonary veins (PVs) potentially generate ectopic automaticity in response to noradrenaline (NA), and thereby trigger atrial fibrillation. We developed a mathematical model of rat PV cardiomyocytes (PVC) based on experimental data that incorpor...

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Bibliographic Details
Main Authors: Shohei Umehara, Xiaoqiu Tan, Yosuke Okamoto, Kyoichi Ono, Akinori Noma, Akira Amano, Yukiko Himeno
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
rat pulmonary vein cardiac myocyte
automaticity
α1- and β1-adrenoceptor
InsP<sub>3</sub>R
IP<sub>3</sub>
Online Access:https://www.mdpi.com/1422-0067/20/12/2913

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https://www.mdpi.com/1422-0067/20/12/2913

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