Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis

Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis

Abstract Background Ferritin plays a central role in the intracellular iron metabolism; the molecule is a nanocage of 24 subunits of the heavy and light types. The heavy subunit (FHC) is provided of a ferroxidase activity and thus performs the key transformation of iron in a non-toxic form. Recently...

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Bibliographic Details
Main Authors: I. Aversa, F. Zolea, C. Ieranò, S. Bulotta, A. M. Trotta, M. C. Faniello, C. De Marco, D. Malanga, F. Biamonte, G. Viglietto, G. Cuda, S. Scala, F. Costanzo
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ferritin heavy chain
EMT
CXCR4
CXCL12
Cancer
ROS
Online Access:http://link.springer.com/article/10.1186/s13046-017-0571-8

Internet

http://link.springer.com/article/10.1186/s13046-017-0571-8

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