miRNA Enriched in Human Neuroblast Nuclei Bind the MAZ Transcription Factor and Their Precursors Contain the MAZ Consensus Motif

miRNA Enriched in Human Neuroblast Nuclei Bind the MAZ Transcription Factor and Their Precursors Contain the MAZ Consensus Motif

While the cytoplasmic function of microRNA (miRNA) as post-transcriptional regulators of mRNA has been the subject of significant research effort, their activity in the nucleus is less well characterized. Here we use a human neuronal cell model to show that some mature miRNA are preferentially enric...

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Bibliographic Details
Main Authors: Belinda J. Goldie, Chantel Fitzsimmons, Judith Weidenhofer, Joshua R. Atkins, Dan O. Wang, Murray J. Cairns
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
nuclear miRNA
primate-specific
regulation of gene expression
neuron differentiation
Argonaute proteins
splicing
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00259/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00259/full

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