SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.

SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.

SIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recently SIRT2 was revealed to play an important role in inflamm...

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Bibliographic Details
Main Authors: Giuseppe Lo Sasso, Keir Joe Menzies, Adrienne Mottis, Alessandra Piersigilli, Alessia Perino, Hiroyasu Yamamoto, Kristina Schoonjans, Johan Auwerx
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4114785?pdf=render

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