JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix

JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix

Abstract Background Intervertebral disc degeneration (IVDD)-related disorders are the major causes of low back pain. A previous study suggested that Notch activation serves as a protective mechanism and is a part of the compensatory response that maintains the necessary resident nucleus pulposus (NP...

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Bibliographic Details
Main Authors: Jun Long, Xiaobo Wang, Xianfa Du, Hehai Pan, Jianru Wang, Zemin Li, Hui Liu, Xudong Li, Zhaomin Zheng
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Arthritis Research & Therapy
Subjects:
Low back pain
Intervertebral disc degeneration
Nucleus pulposus cell
Notch signaling
Online Access:http://link.springer.com/article/10.1186/s13075-019-1990-z

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http://link.springer.com/article/10.1186/s13075-019-1990-z

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