Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for precl...

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Bibliographic Details
Main Authors: Tara R. Richman, Henrik Spåhr, Judith A. Ermer, Stefan M. K. Davies, Helena M. Viola, Kristyn A. Bates, John Papadimitriou, Livia C. Hool, Jennifer Rodger, Nils-Göran Larsson, Oliver Rackham, Aleksandra Filipovska
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11884

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https://doi.org/10.1038/ncomms11884

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