Manipulation of NKG2D ligands by cytomegaloviruses: impact on innate and adaptive immune response
NKG2D is a potent activating receptor expressed on NK cells, NKT cells, γδ T cells and CD8 T cells. NKG2D recognizes cell surface molecules structurally related to MHC class I proteins induced by infection or other type of cellular stress. The engagement of NKG2D leads to NK cell cytotoxicity and cy...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00085/full |