Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer’s Disease

Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer’s Disease

The pathogenesis of Alzheimer’s disease (AD) involves activation of many NLRP3 inflammatory bodies, which may be related to amyloid β peptide and aggregation of misfolded proteins. Autophagy is an important regulator of inflammatory bodies. However, autophagy shows dynamic changes in the development...

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Bibliographic Details
Main Authors: Wen Zhou, Deng Xiao, Yueyang Zhao, Botao Tan, Zhimin Long, Lehua Yu, Guiqiong He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
NLRP3 inflammasome
autophagy
TFEB
transgenic mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.629891/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.629891/full

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