Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles

Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles

An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies. We have previously synthesized and characterized aromatic compounds that inhibit protease-resistant prion protein (PrPRes) accumulati...

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Main Authors: CLAUDIA P. FIGUEIREDO, NATALIA C. FERREIRA, GISELLE F. PASSOS, ROBSON DA COSTA, FERNANDA S. NEVES, CLARICE S.C. MACHADO, ALESSANDRA MASCARELLO, LOUISE D. CHIARADIA-DELATORRE, PATRÍCIA D. NEUENFELDT, RICARDO J. NUNES, YRAIMA CORDEIRO
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2015-08-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
prion
toxicidade aguda
composto orgânico
segurança de fármacos
scrapie
farmacocinética
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301421&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301421&lng=en&tlng=en

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