Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors

Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors

Chronic stress is a key risk factor for depression, and microglia have been implicated in the pathogenesis of the disease. Recent studies show that the Nod-like receptor protein 3 (NLRP3) inflammasome is expressed in microglia and may play a crucial role in depression. However, the mechanism of NLRP...

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Bibliographic Details
Main Authors: Xiujing Feng, Yuan Zhao, Tianyuan Yang, Manyu Song, Chaoran Wang, Yujie Yao, Honggang Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
stress
glucocorticoid
NLRP3 inflammasome
hippocampal microglia
neuroinflammation
depressive-like behaviors
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00210/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00210/full

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